کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4209513 1280486 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ghrelin and leptin levels in young adults with cystic fibrosis: Relationship with body fat
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Ghrelin and leptin levels in young adults with cystic fibrosis: Relationship with body fat
چکیده انگلیسی

BackgroundGhrelin and leptin are hormones implicated in energy balance coordination and body weight regulation. There are conflicting data regarding the levels and role of leptin while ghrelin has not been studied in CF. The aim of this study was to investigate fasting serum ghrelin and leptin levels in CF adolescents as compared to healthy controls and analyze their association with body fat.MethodsFourteen CF adolescents having pancreatic insufficiency and twenty healthy adolescents were enrolled in the study. Diabetic patients were excluded. In all participants' height, weight, body mass index (BMI) and body fat % (BF %) were estimated. Ghrelin and leptin levels were determined after an overnight fast.ResultsWeight, BMI and BF% were significantly lower in CF adolescents than those of controls. Fasting leptin levels in CF were significantly higher in CF patients (p = 0.030), compared to controls and significantly lower in CF males as compared to CF females (p = 0.01). Fasting ghrelin levels were significantly lower in CF males as compared to male controls (p < 0.001) and comparable in females.ConclusionsAs the overall clinical outcome of CF patients is related to the nutritional status and body weight, the role of ghrelin and leptin in these patients needs to be elucidated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 6, Issue 4, July 2007, Pages 293–296
نویسندگان
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