کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4211054 1280623 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bronchial hyperresponsiveness decreases through childhood
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Bronchial hyperresponsiveness decreases through childhood
چکیده انگلیسی

SummaryLimited knowledge exists about development of bronchial hyperresponsiveness (BHR) through adolescence. We aimed to assess changes in and risk factors for BHR in adolescence.From a Norwegian birth cohort 517 subjects underwent clinical examinations, structured interviews and methacholine challenges at age 10 and 16. BHR was divided into four categories: no BHR (cumulative methacholine dose required to reduce FEV1 by 20% (PD20) >16 μmol), borderline BHR (PD20 ≤16 and >8 μmol), mild to moderate BHR (PD20 ≤8 and >1 μmol), and severe BHR (PD20 ≤ 1 μmol). Logistic regression analysis was used to assess risk factors and possible confounders.The number of children with PD20 ≤ 8 decreased from 172 (33%) to 79 (15%) from age 10–16 (p < 0.001). Most children (n = 295, 57%) remained in the same BHR (category) from age 10–16 (50% with no BHR), whereas the majority 182 (82%) of the 222 children who changed BHR category, had decreased severity at age 16. PD20 ≤ 8 at age 10 was the major risk factor for PD20 ≤ 8 6 years later (odds ratio 6.3), without significant confounding effect (>25% change) of gender, active rhinitis, active asthma, height, FEV1/FVC, or allergic sensitization.BHR decreased overall in severity through adolescence, was stable for the majority of children and only a minority (8%) had increased BHR from age 10 to 16. Mild to moderate and severe BHR at age 10 were major risk factors for PD20 ≤ 8 at 16 years and not modified by asthma or body size.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 106, Issue 2, February 2012, Pages 215–222
نویسندگان
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