کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4211590 | 1280646 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Comparison of the efficacy of salmeterol/fluticasone propionate combination in Japanese and Caucasian asthmatics Comparison of the efficacy of salmeterol/fluticasone propionate combination in Japanese and Caucasian asthmatics](/preview/png/4211590.png)
SummaryIntroductionThe effect of ethnicity on the efficacy of salmeterol (S)+fluticasone propionate (FP) has not been examined in Japanese and Caucasian asthmatics. In this study, the efficacy of combination treatment with S and FP from a single inhaler (SFC) was compared with concurrent treatment with S and FP administration from separate inhalers (S+FP) in Japanese and Caucasian asthmatics.MethodsThis was a randomised, double-blind, crossover study in male and female Japanese (n=18) and Caucasian (n=17) asthmatics (50–100% predicted FEV1; >35% reversibility in sGaw). Subjects received SFC (S 50 mcg/FP 250 mcg b.i.d.) and S+FP (S 50 mcg b.i.d.+FP 250 mcg b.i.d.) for 14 days. sGaw and FEV1 were determined 0–12 h after the first and last doses.ResultsTreatment with both SFC and S+FP produced marked bronchodilation, which was maintained 0–12 h after the first dose. Baseline sGaw and FEV1 increased up to 51% and 180 mL, respectively, in Japanese subjects over 2 weeks of treatment, with similar improvements in Caucasian subjects. On Day 14 the 0–12 h S+FP:SFC treatment ratios (90% CI) for sGaw AUC and peak were 1.05 (0.98, 1.12) and 1.05 (0.97, 1.14), respectively, in Japanese subjects, and 0.99 (0.92, 1.07) and 0.98 (0.89, 1.07), respectively, in Caucasian subjects, with no difference between the two ethnic groups.ConclusionsThe finding of a similar significant bronchodilator response in Japanese and Caucasian asthmatics following concurrent and combination treatment with salmeterol and FP suggests that the therapeutic response to these agents is comparable and independent of ethnicity in Japanese and Caucasian asthma patients.
Journal: Respiratory Medicine - Volume 101, Issue 12, December 2007, Pages 2488–2494