کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4212011 | 1280660 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Calcium stone lithoptysis in primary ciliary dyskinesia Calcium stone lithoptysis in primary ciliary dyskinesia](/preview/png/4212011.png)
SummaryBackgroundAn association between lithoptysis and primary ciliary dyskinesia (PCD) has not been previously reported. However, reports of lithoptysis from 2 older patients (>60 yr) prompted a study of this association.MethodsWe performed a prospective study of all PCD patients presenting to our institution between August 2003 and March 2006, seeking the symptom of lithoptysis or calcium deposition on radiology. A retrospective analysis of all PCD patients presenting prior to August 2003 was also performed. Patients age⩾40 previously reviewed were recontacted. If a history of lithoptysis or calcium deposition was present, we further reviewed radiographic, microbiologic, and biochemical data, including serum calcium and phosphate. Broncholiths were analyzed by light and electron microscopy- and electron-dispersive X-ray analysis.ResultsIn total, 142 patients (n=28n=28 age⩾40) were included, 41 in the prospective and 91 in the retrospective study. Lithoptysis was reported in 5 patients (all age⩾40). Chest CT scans identified calcification (4/5), involving bronchiectatic airways in 3 patients and focal nodular calcification in 1 patient. Two other patients (age 46, 59) were identified with airway calcification without lithoptysis. Available broncholiths from 2 of these patients were composed of calcite, whereas a broncholith from 1 patient with focal nodular calcification contained calcium phosphate. Sputum was positive for Pseudomonas aeruginosa in all 7 patients, but negative for mycobacterial and fungal cultures.ConclusionThere is an association between lithoptysis and PCD in patients age⩾40. We hypothesize that calcite stone formation is a biomineralization response to chronic airway inflammation and retention of infected airway secretions in PCD in a subset of PCD patients.
Journal: Respiratory Medicine - Volume 101, Issue 1, January 2007, Pages 76–83