Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection

PurposeTo compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection.MethodsTwo radiologists assessed 51 confirmed HCCs on MRI in HBV (n = 18) or HCV (n = 33) patients; a third, more experienced, radiologist resolved discrepancies.ResultsArterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P = .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073–0.088)]. Tumors were larger in HBV (P ≤ .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different.ConclusionLarger studies are required to confirm these preliminary findings.