Topographical Arrangement of α- and β-Cells Within Neo-islet Tissues Engineered by Islet Cell Sheet Transplantation in Mice

Reassembly of α and β cells occurred in neo-islet tissues engineered by sheet transplantation. The unique cellular arrangements in neo-islet tissues, which were similar to those in naïve pancreatic islets, may contribute to their longevity and long-term function.