کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4256442 1284523 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ischemia Time and Liver Transplantation, Today
ترجمه فارسی عنوان
زمان اسکیزوفرنی و پیوند کبدی، امروز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

The aim of our study was to retrospectively evaluate the impact of ischemia time and other clinical factors on the development of liver allograft primary nonfunction (PNF). We enrolled 531 consecutive liver transplantations from 1998 to 2013, identifying 10 PNF (1.9%). PNF was found to be statistically related to 4 different variables: donor age >60 years (P = .01), female donor gender (P = .01), total ischemia time >10 hours (P = .03) and infusion of more than 30 fresh frozen plasma units during surgery (P = .02). The study focused on the clinical impact of total ischemia time. We grouped total ischemia time into 4 groups (Group 1: ≤7.5 hours; Group 2: between 7.5 and 10 hours; Group 3: between 10 and 12 hours; Group 4: >12 hours) and 2 groups (assigning a cut-off value of 10 hours): both these grouping systems significantly influenced the development of PNF and 1-year graft survival, with limited impact on long-term survival. We split total ischemia time in a “technical time,” “hepatectomy time,” and “warm ischemia time.” Only the first 2 components were found to be statistically related to PNF development with P = .02 and P = .003, respectively. Further studies should focus on these aspects of PNF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 46, Issue 7, September 2014, Pages 2295–2299
نویسندگان
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