کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4257607 | 1284547 | 2015 | 6 صفحه PDF | دانلود رایگان |
• We reported the survival data on renal transplantation from our center.
• Elevated creatinine levels of ≥1.5 mg/dL at 1 month and proteinuria ≥500 mg/d at 1 year after transplantation were risk factors for a poor 5-year graft survival.
• Serum creatinine within the 1st month after transplantation seems to be an important parameter influencing the long-term survival.
• Delayed graft function is an important factor of poor graft survival.
• Modern immunosuppressive drugs seem to help to achieve a better survival.
ObjectiveData on transplantation survival is widely available for developed countries where cadaveric transplantation is the dominant transplantation type. We aimed to assess patient and graft survival and to determine the possible factors affecting graft survival in a developing country where kidney transplantations were mainly performed from living donors.MethodsWe retrospectively analyzed data from 427 adult kidney transplantations performed at our center from January 1990 to November 2010. We collected data from patient files, including characteristics of the recipients and donors, transplantation-related factors, post-transplantation features, causes of graft loss, and patient death. The Kaplan-Meier method was used to analyze survival, and Cox regression analysis was used to evaluate the effects of multiple factors on graft survival.ResultsMost of the recipients (82.6%) received their organs from living donors. One-year and 5-year graft survival rates were 87.5% and 78.3%, respectively, where the 5-year graft survival rates were 87.1% for living donors and 74.8% for cadaveric donors. The 1-year and 5-year patient survival rates were 90.9% and 88.9%, respectively. Univariate analysis showed that predictors for better graft survival were serum creatinine levels <1.5 mg/dL at 1 month after transplantation, proteinuria <500 mg/d at 1 year after transplantation, use of tacrolimus and mycophenolic acid derivative–based immunosuppression at baseline, living-donor transplantation, and transplantations performed in the years 2000–2010.ConclusionsWe report data on kidney transplantation in an emerging country where living-donor transplantation constitutes a large proportion of kidney transplant activities. Modern immunosuppressive medications help to achieve a better survival. Our 5-year results are similar to those of developed countries.
Journal: Transplantation Proceedings - Volume 47, Issue 2, March 2015, Pages 348–353