کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4257643 1284547 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Role of the Killer Cell Immunoglobulin-Like Receptor (KIR) “Missing Self” Model in Unrelated Donor HSCT: A Meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
The Role of the Killer Cell Immunoglobulin-Like Receptor (KIR) “Missing Self” Model in Unrelated Donor HSCT: A Meta-analysis
چکیده انگلیسی


• Killer cell immunoglobulin-like receptor (KIR) ligand compatibility or incompatibility influences the prognosis of hematopoietic stem cell transplantation between unrelated individuals, although the conclusions of these studies are controversial.
• We performed a meta-analysis concerning unrelated donor transplantation with donor-recipient KIRs compatible or incompatible.
• Incompatibility in KIR ligands favors 5-year overall survival but has no effect on the incidence of grade 2 to 4 acute graft-vs-host disease, relapse, or transplantation/treatment-related mortality.
• No differences were observed in the incidence of grade 2 to 4 acute graft-vs-host disease, 5-year relapse rate, or transplantation/treatment-related mortality.

Some studies have found that donor-recipient killer cell immunoglobulin g–like receptor (KIRs) ligand compatibility or incompatibility influences the prognosis of hematopoietic stem cell transplantation between unrelated individuals, although the conclusions of these studies are controversial. We performed a meta-analysis concerning unrelated donor transplantation with donor-recipient KIRs compatible or incompatible. A higher 5-year overall survival rate (odds ratio [OR] = 1.93, 95% confidence interval [CI] = 1.03 to 3.61, P = .04) was found in KIR-mismatched transplantations; however, no difference was observed in the incidence of grade 2 to 4 acute graft-vs-host disease (OR = 0.94, 95% CI = 0.71 to 1.24, P = .64), 5-year relapse rate (OR = 1.05, CI = 0.75 to 1.47, P = .77), or transplantation/treatment-related mortality (OR = 0.61, CI = 0.15 to 2.51, P = .50). Our meta-analysis confirmed that incompatibility in KIR ligands favors 5-year overall survival rate but has no effect on the incidence of grade 2 to 4 acute graft-vs-host disease, relapse, or transplantation/treatment-related mortality.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 47, Issue 2, March 2015, Pages 558–565
نویسندگان
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