کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4258273 | 1284555 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Myeloid Differentiation Factor 88-Silenced Bone Marrow-Derived Dendritic Cells Exhibit Enhanced Tolerogenicity in Intestinal Transplantation in Rats
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل جراحی
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![عکس صفحه اول مقاله: Myeloid Differentiation Factor 88-Silenced Bone Marrow-Derived Dendritic Cells Exhibit Enhanced Tolerogenicity in Intestinal Transplantation in Rats Myeloid Differentiation Factor 88-Silenced Bone Marrow-Derived Dendritic Cells Exhibit Enhanced Tolerogenicity in Intestinal Transplantation in Rats](/preview/png/4258273.png)
چکیده انگلیسی
Myeloid differentiation factor 88 (MyD88) is a key adaptor of Toll-like receptor signaling, which plays a critical role in dendritic cell (DC) function. However, its role in the induction of transplant tolerance by immature DCs is unknown. In this study, we silenced MyD88 expression of bone marrow-derived immature DCs with small interference RNA demonstrating that this maneuver significantly prolonged the survival of intestinal allografts. This study provided evidence that the absence of MyD88 enhances the tolerogenicity of DCs and suggested that inhibiting innate immunity may be a potential strategy to facilitate induction of transplant tolerance by DCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 40, Issue 5, June 2008, Pages 1625-1628
Journal: Transplantation Proceedings - Volume 40, Issue 5, June 2008, Pages 1625-1628
نویسندگان
C. Zhu, H. Xu, G. Zhang, C. Lu, M. Ji, W. Wu,