کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4258787 1284562 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Universal Valganciclovir Prophylaxis Significantly Reduces Episodes of First-Year Cytomegalovirus Disease and Biopsy-Proven Acute Rejection in Kidney Transplant Recipients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Universal Valganciclovir Prophylaxis Significantly Reduces Episodes of First-Year Cytomegalovirus Disease and Biopsy-Proven Acute Rejection in Kidney Transplant Recipients
چکیده انگلیسی

BackgroundCytomegalovirus (CMV) remains the most critical viral pathogen after kidney transplantation (KTx). The universal prophylaxis, but not pre-emptive therapy, could avoid the wide range of indirect effects induced by CMV infection. This study aims to examine the effect of universal prophylaxis with oral valganciclovir for the first year of CMV disease after KTx.MethodsThe universal prophylaxis therapy was started in May 2008. Patients who received KTx between January 2006 and September 2010 were included in the study. Oral valganciclovir (Valcyte) was used for 3 months with dosage adjusted by eGFR. CMV disease was defined by typical CMV syndrome with positive viremia or tissue proven. The study end points are episode of CMV disease and first-year biopsy-proven acute rejection.ResultsIn total, 68 KTx patients who received universal prophylaxis for 3 months (study group) and another 50 KTx recipients without universal prophylaxis (control group) were enrolled. The incidence of CMV disease was 8.0% (4 of 50) in the control group. The universal prophylaxis significantly reduced the first-year episodes of CMV disease to 0% (0 of 68). There were 8 episodes of biopsy-proven acute rejection (8 of 50, 16%) within 1 year after KTx in the control group, but only 2 episodes of biopsy-proven acute rejection (2 of 68, 2.9%) in the treatment group (P < .05).ConclusionsUniversal prophylaxis with oral valganciclovir for 3 months significantly reduced episodes of first-year CMV disease and biopsy-proven acute rejection in kidney transplant recipients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Proceedings - Volume 46, Issue 2, March 2014, Pages 574–577
نویسندگان
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