کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4259174 | 1284567 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Correlation Between CD14+CD16++ Monocytes in Peripheral Blood and Hypertriglyceridemia After Allograft Renal Transplantation Correlation Between CD14+CD16++ Monocytes in Peripheral Blood and Hypertriglyceridemia After Allograft Renal Transplantation](/preview/png/4259174.png)
BackgroundCardio-cerebrovascular diseases are key factors causing recipient the death after kidney transplantation (KT). Hypertriglyceridemia (HTG), a complication commonly occurring among KT patients, is a major risk factor for cardio-cerebrovascular diseases. The objective of this study was to examine the correlation between peripheral CD14+CD16++ monocytes in KT patients and blood lipids as well as factors affecting hyperglycemia, seeking to understand mechanisms of inflammatory immune reactions.MethodsKT patients (n = 60) were divided into subjects with HTG (n = 35) versus without HTG (n = 25). A cohort of healthy participants (55 cases) was divided into the cases without (n = 30) versus with HTG (n = 25). The proportion of peripheral CD14+CD16 ++ monocytes was determined using flow cytometry and hematology, and biochemical indicators were measured by conventional methods. We correlated HTG with these indicators.ResultsThe proportion of peripheral blood CD14+CD16++ monocytes among the renal transplant group was significantly lower (P < .05) than that of normal controls. The expression of CD14+CD16++ monocytes among transplant recipients positively correlated with triglycerides (R = 0.449 and R = 0.008, respectively).ConclusionCD14+CD16++ mononcytes in peripheral blood may represent an independent risk factor for HTG after KT.
Journal: Transplantation Proceedings - Volume 45, Issue 9, November 2013, Pages 3279–3283