کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4259299 | 1284568 | 2009 | 4 صفحه PDF | دانلود رایگان |
Understanding the relationships among immune cells in the setting of immunologic tolerance is imperative to maintain organ and tissue transplants. T cells and natural killer (NK) cells are responsible for both immune tolerance and immune rejection; however, there is only limited knowledge about the relevance of T and NK cells in tolerance. To address this issue, we explored the possible actions of tolerant T cells on NK cells by the means of mixed lymphocyte co-cultures and NK cytotoxicity assays. We showed that tolerant T cell–induced blockade of the co-stimulatory pathway significantly inhibited NK cell function in vitro regarding antigen-presenting cells. This action was cell-cell–contact dependent. We argue that tolerant T cells and NK cells impart synergistic cooperation to maintain transplant tolerance.
Journal: Transplantation Proceedings - Volume 41, Issue 5, June 2009, Pages 1844–1847