کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4259686 | 1284575 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Preischemic Iloprost Application for Improvement of Graft Preservation: Which Route is Superior in Experimental Pig Lung Transplantation: Inhaled or Intravenous? Preischemic Iloprost Application for Improvement of Graft Preservation: Which Route is Superior in Experimental Pig Lung Transplantation: Inhaled or Intravenous?](/preview/png/4259686.png)
BackgroundOptimal allograft protection is essential in lung transplantation to reduce postoperative organ dysfunction. Although intravenous prostanoids are routinely used to ameliorate reperfusion injury, the latest evidence suggests a similar efficacy of inhaled prostacyclin. Therefore, we compared donor lung-pretreatment using inhaled lioprost (Ventavis) with the commonly used intravenous technique.MethodsFive pig lungs were each preserved with Perfadex and stored for 27 hours without (group 1) or with (group-2, 100 prior aerosolized of iloprost were (group 3) or iloprost (IV). Following left lung transplantation, hemodynamics, Po2/Fio2, compliance, and wet-to-dry ratio were monitored for 6 hours and compared to sham controls using ANOVA analysis with repeated measures.ResultsThe mortality was 100% in group 3. All other animals survived (P < .001). Dynamic compliance and PVR were superior in the endobronchially pretreated iloprost group as compared with untreated organs (P < .05), whereas oxygenation was comparable overall W/D-ratio revealed significantly lower lung water in group 2 (P = .027) compared with group 3.ConclusionPreischemic alveolar deposition of iloprost is superior to IV pretreatment as reflected by significantly improved allograft function. This strategy offers technique to optimize pulmonary preservation.
Journal: Transplantation Proceedings - Volume 39, Issue 5, June 2007, Pages 1345–1349