Hyperbaric Oxygenation Attenuates Renal Ischemia–Reperfusion Injury in Rats

BackgroundOxygen-derived free radicals play an important role in ischemia–reperfusion injury (IR). Hyperbaric oxygenation (HO) decreases free radical production. The aim of this study was to determine the effect of HO treatment on renal ischemia–reperfusion injury in rats.MethodsRats were divided into four groups. All groups underwent right nephrectomy. Group I served as the control group; group II had left renal ischemia–reperfusion; group III was pretreated with HO; and group IV, ischemia–reperfusion and HO pretreatment. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured, and histopathologic damage scored.ResultsHO pretreatment significantly decreased tissue MDA levels and histopathologic scores among rats with IR. There was an increased GSH in HO-pretreated rats with IR; however, the difference was not significant.ConclusionHO prior to ischemia displayed a beneficial effect on renal IR by reducing oxygen radical peroxidation of lipid membranes.