Ischemic Preconditioning Improves Rat Kidney Allograft Function After Ischemia/Reperfusion Injury: The Role of Tumor Necrosis Factor-Alpha

A 1-cycle schedule of preconditioning (15 min/10 min) attenuated renal graft ischemia/reperfusion injury in the early phase. IPC can improve rat kidney allograft function after ischemia/reperfusion injury. The inhibitory effects on TNF-α and on positive feedback signaling of TNF-α/NF-κB pathways may play important roles in renal graft protection in the early stage.