The Role of Fcγ Receptor Gene Polymorphism in Pediatric Renal Transplant Rejections

The aim of the study reported herein was to determine whether panel-reactive antibody (PRA) and FcγR gene polymorphism act in the same way on acute rejection (AR) and chronic rejection (CR) in children who have undergone renal transplantation. The study evaluated 56 children who underwent transplantation and 115 healthy subjects. AR was observed in 13 cases; CR was observed in 7 patients. The assessment for FcγR of the groups in which AR was present showed statistical significance only for the FcγIIA genotype. There was no statistical significance for either the FcγIIIA or FcγIIIB genotypes. Assessment of the FcγIIA, IIIA, and IIIB genotypes of the groups in whom CR was present did not show statistical significance. As a result, the prediction of graft survival among transplant recipients is possible using molecular biology. The results of our study showed that individuals of the FcγRIIA genotype seemed to have a poorer prognosis similar to some autoimmune diseases. These individuals constitute a risk group for AR. If other studies are conducted with more patients to demonstrate the relationship of other FcγRs to rejection, the resultant predictive knowledge about the value of genotypes may lead to improved outcomes following renal transplantation.