Nitric Oxide and Thromboxane A2 Modulate Pulmonary Pressure After Ischemia and Intestinal Reperfusion

IR-induced pulmonary dysfunction is caused by increased vascular resistance and increased perfusion pressure. These changes are, at least in part, due to the ongoing release of TxA2. Administration of 8Br-cGMP protected against TxA2-induced vasoconstriction.