کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4262034 | 1284601 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Augmentor of Liver Regeneration Ameliorates Renal Tubular Epithelial Cell Injury After Rat Liver Transplantation Augmentor of Liver Regeneration Ameliorates Renal Tubular Epithelial Cell Injury After Rat Liver Transplantation](/preview/png/4262034.png)
BackgroundAcute renal insufficiency and dysfunction are common complications after clinical liver transplantation. This study examined whether augmentor of liver regeneration (ALR) played a significant role to ameliorate renal tubular epithelial cell injury after liver transplantation.MethodsOrthotopic liver transplantation was performed from Sprague-Dawley (SD) to SD rats. Twelve recipients were randomly divided into two groups: ALR group (with recombinated human ALR 100 μg/kg · d intramuscular injection postoperation) versus normal saline-treated group (with the same volume of normal saline injected intramuscularly postoperation). Rats were sacrificed at day 3 posttransplantation. Renal morphological changes in recipients were assessed with light microscopy. The expressions of tumor necrosis factor-α (TNF-α), proliferating cell nuclear antigen (PCNA) and caspase-3 protein and mRNA in the kidney were evaluated by real-time polymerase chain reaction and immunohistochemical staining.ResultsMorphological changes in renal tubular epithelial cells were not significant in either group at day 3 posttransplantation. The intragraft expression of TNF-α and caspase-3 was strikingly promoted in the normal saline-treated group and PCNA attenuated compared to the ALR group.ConclusionThese data suggested that ALR may play a role to reduce renal damage in liver transplant recipients.
Journal: Transplantation Proceedings - Volume 40, Issue 8, October 2008, Pages 2696–2699