کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4262113 | 1284602 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Is There a Differential Strength of Specific HLA Mismatches in Kidney Transplants? Is There a Differential Strength of Specific HLA Mismatches in Kidney Transplants?](/preview/png/4262113.png)
In this article we attempted to identify whether there is a specific mismatched antigen that might be detrimental to kidney transplant outcome. The frequency of function versus failure of transplant cases was tallied within subpopulations among a subset of the 2006 United Network for Organ Sharing transplant dataset. We examined 7998 cadaveric and 11,420 living donor kidney transplants that were mismatched for a single class I antigen. When tested by five different criteria, the results were relatively similar for the HLA class I, A- and B-locus mismatches. HLA A1 was identified as the single most dominant immunogenic mismatch. However, when the P values were multiplied by 68, the number of comparisons, A1 was only marginally significant. We concluded that at least for class I specificities, the 68 specificities were about equal immunogenicity in kidney transplantation.
Journal: Transplantation Proceedings - Volume 40, Issue 4, May 2008, Pages 1091–1094