کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4266078 | 1284700 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
عمل پیوند
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![عکس صفحه اول مقاله: Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing Enteric-coated mycophenolate sodium immunosuppression in renal transplant patients: efficacy and dosing](/preview/png/4266078.png)
چکیده انگلیسی
Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient outcomes. Enteric-coated mycophenolate sodium (EC-MPS) delivers equivalent MPA exposure to MMF and offers the potential to reduce GI burden (while maintaining patient safety). Here we review the efficacy of EC-MPS compared with MMF in renal transplant patients in terms of biopsy-proven acute rejection and graft loss, and examine the use of EC-MPS in newer regimens such as intensified dosing and calcineurin inhibitor minimization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transplantation Reviews - Volume 26, Issue 4, October 2012, Pages 233–240
Journal: Transplantation Reviews - Volume 26, Issue 4, October 2012, Pages 233–240
نویسندگان
Matthew Cooper, Maurizio Salvadori, Klemens Budde, Frederic Oppenheimer, Hans Sollinger, Martin Zeier,