کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4269594 1610849 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nitrergic Function Is Lost but Endothelial Function Is Preserved in the Corpus Cavernosum and Penile Resistance Arteries of Men after Radical Prostatectomy
ترجمه فارسی عنوان
تابع نیتروژنی از دست رفته است اما تابع اندوتلیال در شریانهای قوای مغزی و قوام مردان پس از پروستاتکتومی رادیکال حفظ می شود
کلمات کلیدی
اختلال نعوظ، پروستاتکتومی رادیکال، انسانی کورنووسوم، استراحت وابسته به اندوتلیوم، آرامش نیتروژیک، توانبخشی پنیری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی اورولوژی
چکیده انگلیسی

IntroductionRadical prostatectomy (RP) frequently results in erectile dysfunction (ED). It has been hypothesized that alterations of cavernosal tissue subsequent to RP contribute to ED but functional evaluation of the impact of RP on human erectile structures is lacking.AimThis study aims to evaluate endothelial function of human corpus cavernosum (HCC) and human penile resistance arteries (HPRA) and neurogenic responses of HCC from patients with ED secondary to RP (ED‐RP).MethodsHCC strips and HPRA were obtained from organ donors without history of ED (No‐ED) and patients with ED who were segregated depending on ED etiology: ED‐RP or vasculogenic (ED‐VASC). Functional evaluation of HCC and HPRA was performed in organ chambers and wire myographs, respectively. Histological evaluation of cavernosal tissue consisted of trichrome staining for fibrosis quantification and TUNEL assay for determination of apoptosis.Main Outcome MeasuresEndothelium‐dependent and endothelium‐independent relaxation, electrical field stimulation (EFS)‐induced neurogenic contraction and relaxation, and cavernosal fibrosis and apoptosis.ResultsEndothelium‐dependent relaxations were significantly impaired in HCC and HPRA from ED‐VASC patients while these responses in ED‐PR patients were not different to No‐ED. Similarly, sildenafil‐induced relaxations were reduced in HCC and HPRA from ED‐VASC but were preserved in ED‐RP. Adrenergic contractions induced by EFS in HCC were potentiated in both ED‐RP and ED‐VASC. EFS‐induced nitrergic relaxation was significantly reduced in HCC from ED‐VASC but was almost abolished in ED‐RP. Fibrous tissue content and cavernosal apoptosis in HCC from ED‐RP were not significantly different from No‐ED.ConclusionsEndothelial function and cavernosal sensitivity to phosphodiesterase type 5 inhibitors are preserved in erectile tissue from ED‐RP while a marked imbalance in neurogenic modulation of cavernosal tone favoring adrenergic contractile responses over nitrergic relaxation is manifested. Fibrotic and apoptotic processes in cavernosal tissue are not specifically associated to ED‐RP. These evidences could help to retarget therapeutic strategies in the management of ED after RP. Martínez‐Salamanca JI, La Fuente JM, Fernández A, Martínez‐Salamanca E, Pepe‐Cardoso AJ, Carballido J, and Angulo J. Nitrergic function is lost but endothelial function is preserved in the corpus cavernosum and penile resistance arteries of men after radical prostatectomy. J Sex Med 2015;12:590–599.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Sexual Medicine - Volume 12, Issue 3, March 2015, Pages 590–599
نویسندگان
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