Tadalafil Effect on Metabolic Syndrome‐Associated Bladder Alterations: An Experimental Study in a Rabbit Model

Tadalafil dosing reduced RhoA/ROCK signaling and smooth muscle overactivity in an animal model of MetS‐associated bladder alterations. Our findings suggest a novel mechanism of action of tadalafil in alleviating LUTS in MetS patients. Vignozzi L, Filippi S, Comeglio P, Cellai I, Morelli A, Maneschi E, Sarchielli E, Gacci M, Carini M, Vannelli GB, and Maggi M. Tadalafil effect on metabolic syndrome‐associated bladder alterations: An experimental study in a rabbit model. J Sex Med 2014;11:1159-1172.