Motivated Behaviors and Levels of 3α,5α-THP in the Midbrain Are Attenuated by Knocking Down Expression of Pregnane Xenobiotic Receptor in the Midbrain Ventral Tegmental Area of Proestrous Rats

Knockdown of PXR in the midbrain reduces 3α,5α-THP levels and sexual receptivity of proestrous rats. Thus, PXR in the midbrain may be required for the observed increase in 3α-5α-THP during proestrus, which has subsequent effects on motivated, reproductive behaviors. Frye CA, Koonce CJ, Walf AA, and Rusconi JC. Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.