Effects of Icariin on Improving Erectile Function in Streptozotocin‐Induced Diabetic Rats

Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats. Down‐regulation of TGFβ1/Smad2 signaling pathway might mediate this effect. Liu T, Xin H, Li W‐R, Zhou F, Li G‐Y, Gong Y‐Q, Gao Z‐Z, Qin X‐C, Cui W‐S, Shindel AW, and Xin Z‐C. Effects of icariin on improving erectile function in streptozotocin‐induced diabetic rats. J Sex Med 2011;8:2761-2772.