The Effects of Chronic 5‐Alpha‐Reductase Inhibitor (Dutasteride) Treatment on Rat Erectile Function

The 5ARIs, as demonstrated in these rat cavernosal smooth muscle studies, have a detrimental effect on erectile function. Enhanced iNOS expression may protect penile smooth muscle from fibrosis. The effect of 5ARIs on human sexual function warrants further investigation. Pinsky MR, Gur S, Tracey AJ, Harbin A, and Hellstrom WJG. The effects of chronic 5‐alpha‐reductase inhibitor (dutasteride) treatment on rat erectile function. J Sex Med 2011;8:3066-3074.