Corpus Cavernosal Smooth Muscle Relaxation Effect of a Novel AMPK Activator, Beta‐Lapachone

A novel AMPK activator, beta‐lapachone has a strong relaxation effect on precontracted cavernosal smooth muscle strips in the rabbit. And phosphorylation of AMPK and eNOS strongly related to the action of beta‐lapachone. Mevalonate pathway also might be considered as a suggestive mechanism. Bae JH, Kim JW, Kweon GR, Park MG, Jeong K‐H, Kim JJ, and Moon DG. Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta‐lapachone. J Sex Med 2011;8:2205-2214.