Expression of Cyclic AMP-dependent Protein Kinase Isoforms in Human Cavernous Arteries: Functional Significance and Relation to Phosphodiesterase Type 4

Our results demonstrate the expression of cAK isoforms in the smooth musculature of HCA and its colocalization with PDE4. A significant role for cAK in the regulation mediated by cAMP and cGMP of vascular smooth muscle tone in HCA can also be assumed. Waldkirch ES, Ückert S, Sigl K, Satzger I, Geismar U, Langnäse K, Richter K, Sohn M, Kuczyk MA, and Hedlund P. Expression of cyclic AMP-dependent protein kinase isoforms in human cavernous arteries: Functional significance and relation to phosphodiesterase type 4.