The Serotonin Transporter Plays an Important Role in Male Sexual Behavior: A Study in Serotonin Transporter Knockout Rats

Absence of the serotonin transporter reduces basal ejaculatory performance in male rats. Pharmacological experiments suggest that separate pools of 5‐HT1A receptors regulate different aspects of sexual performance in male rats. 5‐HT7 receptors may play a minor role in the partial recovery of sexual behavior after combination of ±8‐OH‐DPAT and WAY100635. The SERT−/− rat may be a model for chronic SSRI treatment, delayed ejaculation, anorgasmia, and/or low libido. Chan JSW, Snoeren EMS, Cuppen E, Waldinger MD, Olivier B, and Oosting RS. The serotonin transporter plays an important role in male sexual behavior: A study in serotonin transporter knockout rats.