Impact of Dry Ejaculation Caused by Highly Selective α1A-blocker: Randomized, Double-blind, Placebo-controlled Crossover Pilot Study in Healthy Volunteer Men

Silodosin may adversely affect the subjective orgasmic function by causing an abnormal ejaculation with decreased (or no) semen discharge and a decrease in the number of bulbocavernosus/pelvic floor muscle contractions. Semen passing through the urethra and sufficient rhythmic contraction of the muscle of the pelvic floor may contribute to the subjective pleasure of orgasm. Shimizu F, Taguri M, Harada Y, Matsuyama Y, Sase K, and Fujime M. Impact of dry ejaculation caused by highly selective α1A-blocker: Randomized, double-blind, placebo-controlled crossover pilot study in healthy volunteer men.