Estrogens Regulate Humans and Rabbit Epididymal Contractility Through the RhoA/Rho-kinase Pathway

Our results suggest that estrogens regulate epididymal motility by increasing RhoA/ROCK signaling, and therefore calcium sensitivity, which tunes up responsiveness to contractile factors. Fibbi B, Filippi S, Morelli A, Vignozzi L, Silvestrini E, Chavalmane A, De Vita G, Marini M, Gacci M, Manieri C, Vannelli GB, and Maggi M. Estrogens regulate humans and rabbit epididymal contractility through the Rhoa/Rho-kinase pathway. J Sex Med 2009;6:2173-2186.