Poly(ADP-Ribose) Polymerase Inhibition Reverses Nitrergic Neurovascular Dysfunctions in Penile Erectile Tissue from Streptozotocin-Diabetic Mice

GPI 15427 treatment provides marked benefits for NO-dependent neurovascular function in diabetic mouse CC. Therefore, PARP-1 inhibition may be worthy of further investigation for diabetes-associated ED. Nangle MR, Cotter MA, and Cameron NE. Poly(ADP-ribose) polymerase inhibition reverses nitrergic neurovascular dysfunctions in penile erectile tissue from streptozotocin-diabetic mice.