ORIGINAL RESEARCH-INTERSEX AND GENDER IDENTITY DISORDERS: Neuroimaging Differences in Spatial Cognition between Men and Male-to-Female Transsexuals Before and During Hormone Therapy

Our results confirmed previously reported deviances of brain activation patterns in transsexual men from men without GID and also corroborated these findings in a group of transsexual patients receiving cross-sex hormone therapy. The present study indicates that there are a priori differences between men and transsexual patients caused by different neurobiological processes or task-solving strategies and that these differences remain stable over the course of hormonal treatment. Schöning S, Engelien A, Bauer C, Kugel H, Kersting A, Roestel C, Zwitserlood P, Pyka M, Dannlowski U, Lehmann W, Heindel W, Arolt V, and Konrad C. Neuroimaging differences in spatial cognition between men and male-to-female transsexuals before and during hormone therapy.