Acute Vardenafil Administration Improves Bladder Oxygenation in Spontaneously Hypertensive Rats

SHR showed bladder hypoxia which was significantly reduced by acute vardenafil treatment. Thus, besides relaxing muscular wall, PDE5 inhibition may positively affect urinary vesicle blood perfusion. Morelli A, Filippi S, Comeglio P, Sarchielli E, Chavalmane AK, Vignozzi L, Fibbi B, Silvestrini E, Sandner P, Gacci M, Carini M, Vannelli GB, and Maggi M. Acute vardenafil administration improves bladder oxygenation in spontaneously hypertensive rats.