Endothelial Nitric Oxide Synthase Regulation in Female Genital Tract Structures

The effects of estrogen on increasing genital blood flow and smooth muscle relaxation have been attributed mostly to regulation of eNOS. However, the exact mechanisms of eNOS regulation in female genital tract structures and the molecular basis for the eNOS defect with aging and vascular diseases warrant further investigation. Musicki B, Liu T, Lagoda GA, Bivalacqua TJ, Strong TD, and Burnett AL. Endothelial nitric oxide synthase regulation in female genital tract structures.