TNF‐α Infusion Impairs Corpora Cavernosa Reactivity

Corpora cavernosa from TNF‐α‐infused mice display increased contractile responses and decreased NANC nerve‐mediated relaxation associated with decreased eNOS and nNOS gene expression. These changes may trigger ED and indicate that TNF‐α plays a detrimental role in erectile function. Blockade of TNF‐α actions may represent an alternative therapeutic approach for ED, especially in pathologic conditions associated with increased levels of this cytokine. Carneiro FS, Zemse S, Giachini FRC, Carneiro ZN, Lima VV, Clinton Webb R, and Tostes RC. TNF‐α infusion impairs corpora cavernosa reactivity.