ORIGINAL RESEARCH-BASIC SCIENCE: Sexually Dimorphic Effects of Testosterone Administration on Brain Allopregnanolone in Gonadectomized Rats

Gender difference and T therapy affect brain AP synthesis/release during the reproductive aging. This effect becomes particularly evident in the brain of ovariectomized animals, where the content of this specific neurosteroid is much more responsive than male animals to testosterone replacement. Pluchino N, Ninni F, Casarosa E, Lenzi E, Begliuomini S, Cela V, Luisi S, Freschi L, Merlini S, Giannini A, Cubeddu A, and Genazzani AR. Sexually dimorphic effects of testosterone administration on brain allopregnanolone in gonadectomized rats. J Sex Med 2008;5:2780-2792.