Increased Intracavernosal Pressure Response in Hypertensive Rats After Chronic Hemin Treatment

Decreased erectile responses in adult SHR can be improved through chronic hemin treatment. Prolonged upregulation of HO‐1 and sGC as well as lowered expression of PDE5 may at least partially explain the effect of hemin treatment on ICP. Upregulation of HO‐1 may represent a novel therapeutic approach to treat ED. Shamloul R, and Wang R. Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. J Sex Med 2006;3:619-627.