Testosterone:Estradiol Ratio Changes Associated with Long‐Term Tadalafil Administration: A Pilot Study

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross‐talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long‐term tadalafil administration: A pilot study. J Sex Med 2006;3:716-722.