ORIGINAL RESEARCH-ENDOCRINOLOGY: Vaginal Application of Testosterone: A Study on Pharmacokinetics and the Sexual Response in Healthy Volunteers

A single dose of vaginally applied testosterone propionate elevates serum levels of testosterone and free testosterone within 6 hours. Nevertheless, this acute rise in androgens has no effects on the female sexual response. Apperloo M, Midden M, van der Stege J, Wouda J, Hoek A, and Weijmar Schultz W. Vaginal application of testosterone: A study on pharmacokinetics and the sexual response in healthy volunteers. J Sex Med 2006;3:541-549.