کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4274846 | 1285296 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
VÃa trasera de la sÃntesis de testosterona (backdoor pathway)
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
اورولوژی
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چکیده انگلیسی
Testosterone is an intracrine hormone that is synthesized from cholesterol, using a cascade of enzymes that is best known of «frontdoor» pathway for production. However, there are at least two alternative adrenal ways for testosterone synthesis also considered «frontdoor» and two «backdoor» pathways that just now are beginning to be recognized with clinical significance. In prostate cancer the presence of testosterone and its by-products is essential, in what is known as the «androgen's hypothesis». Additionally in prostate cancer the remaining amounts of androgens are very important, as well as knowing if the body has some alternate routes to produce the most important androgens, i.e. dihydrotestosterone (DHT). Knowing the «backdoor pathway» and controlling it is fundamental in the current management of prostate cancer. The so-called ultra-castration (or hypercastration) is not the final frontier in the treatment of hormone resistant disease; alternatives related to the androgen receptor as its modification or destruction are in experimentation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: UrologÃa Colombiana - Volume 25, Issue 1, JanuaryâApril 2016, Pages 25-30
Journal: UrologÃa Colombiana - Volume 25, Issue 1, JanuaryâApril 2016, Pages 25-30
نویسندگان
Juan Fernando Uribe Arcila,