Nonchlamydial nongonococcal urethritis in men

By definition, nongonococcal urethritis (NGU) is an infectious condition involving urethra inflammation without Neisseria gonorrhoeae infection. According to recent studies, NGU accounts for 10–30% of initial visits to sexually transmitted infection (STI) clinics, and is one of the most common forms of STI in men. Chlamydia trachomatis is the most prevalent and well-established pathogen in NGU. However, nonchlamydial NGU is still a problematic disease in clinics because of its minimally symptomatic or asymptomatic manifestation. Various infection causes, including Mycoplasma, Trichomonas vaginalis, and herpes simplex virus, are possible pathogens in nonchlamydial NGU. In this brief review, we focus on the evaluation and management of nonchlamydial NGU.