کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4276369 1285399 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recurrent urinary tract infections in healthy and nonpregnant women
ترجمه فارسی عنوان
عفونتهای مجاری ادراری در زنان سالم و غیرقانونی
کلمات کلیدی
جوامع باکتری درون سلولی، زنان بعد از یائسگی، مخزن داخل سلولی محکم، عفونت های مجاری ادراری، عفونت مجدد عوامل خطر برای عفونت های دستگاه ادراری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی اورولوژی
چکیده انگلیسی

Recurrent urinary tract infections (RUTI) are prevalent and pose significant clinical challenges. Although the term RUTI has long been vaguely defined, a consensus definition has emerged in recent years. The exact etiology behind RUTI remains under debate, with valid arguments for both ascending reinfections as well as persistent infection inside the bladder. These persistent infections exist in the form of quiescent intracellular reservoirs in the mouse model and may represent a novel concept to explain UTI recurrence in humans. Manageable risk factors such as behavioral patterns alongside nonmanageable risk factors including genetic susceptibility are growing fields of investigation. Acute UTI have been studied through two model bacterial strains: Escherichia coli UTI89 and CFT073. However, the clinical relevance to RUTI of these two strains has not been firmly established. Current treatment strategies for RUTI are limited and remain dominated by antibiotic usage despite variable efficacy. The majority of studies in humans have focused on younger groups of women with little information available about the postmenopausal population despite a heightened risk of RUTI in this age group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urological Science - Volume 25, Issue 1, March 2014, Pages 1–8
نویسندگان
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