Association Between the Prostate-specific Antigen Gene and the Risk of Prostate Cancer in a Taiwanese Population

ObjectiveWe attempted to determine the association between a G/A polymorphism at position 158 of the prostate-specific antigen (PSA) gene and the risk of prostate cancer in Taiwanese men.Materials and MethodsWe genotyped 149 prostate cancer patients and 176 healthy controls. Logistic regression was used to estimate the odd ratios (ORs) and confidence intervals (CIs).ResultsThe G allele was more frequent than the A allele in both cases and in controls. The A allele was not associated with a significantly higher risk of prostate cancer (odds ratio [OR] = 1.17, confidence interval = 0.78-1.76). GA (OR = 1.18) and AA (OR = 1.19) genotypes were not associated with a significantly higher risk of prostate cancer. In an analysis by disease aggressiveness, aggressive disease had a higher OR than that for nonaggressive disease (1.38 vs. 0.77); however, these associations were not statistically significant.ConclusionsNo association was found between G/A polymorphism and the risk of prostate cancer. Larger studies are necessary to determine whether the A allele is associated with aggressive prostate cancer.