کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4280203 1611550 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis
چکیده انگلیسی

BackgroundThe increasing incidence of thyroid cancer may be an artifact of increased diagnostic scrutiny, permitting detection of smaller, subclinical thyroid cancers. Our objective was to examine trends in the incidence of well-differentiated thyroid cancers with large size and adverse pathological features.MethodsDetailed population-based analysis of incidence trends in well-differentiated thyroid carcinoma (1973–2006) in the Surveillance Epidemiology and End Results (SEER) cancer registry, using weighted least squares and Joinpoint regression models.ResultsThe incidence of well-differentiated thyroid cancer (WDTC) in the United States has tripled since 1973 (P < .0001). Incidence trends differ significantly between geographic regions and racial groups. Large WDTCs, including those >4 cm or >6 cm, have more than doubled in incidence (P < .0001). Cancers with extrathyroidal extension and with cervical metastases have also more than doubled in incidence (P < .0001).ConclusionsWhile the model of improving screening does explain increased diagnoses of small thyroid cancers, significant rises in the incidence of large cancers, and cancers with clinically significant pathological adverse features, are harder to explain. Alternative hypotheses, including a true increase in cancer incidence, would seem to merit exploration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 200, Issue 4, October 2010, Pages 454–461
نویسندگان
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