کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4280401 1611565 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer
چکیده انگلیسی

BackgroundOptimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients.MethodsNinety-three (30%) of 311 patients with ILC received NAC. We examined margin status, residual disease after re-excision, and clinical outcomes.ResultsMargin positivity rates after the final operative procedure were similar between the NAC and surgery-first group (P > .05). The proportion of patients, stratified by margin status, who were taken back for re-excision was not different between the 2 groups, and, similarly, there were no differences in frequency of residual disease (all P > .05). At a median follow-up of 3.1 years, 1 patient in the NAC group and 2 in the surgery-first group developed LR (P = 1.0).ConclusionsPatients with ILC who have undergone NAC and have margins >1 mm have a low probability of residual disease and LR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 198, Issue 3, September 2009, Pages 387–391
نویسندگان
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