کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4281100 | 1611576 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence](/preview/png/4281100.png)
BackgroundMany women with breast cancer recurrence previously treated with breast-conservation therapy desire repeat lumpectomies. We hypothesized that women undergoing mastectomy for breast cancer recurrence would show superior survival.MethodsPatients who previously received breast-conservation therapy diagnosed with an ipsilateral breast cancer recurrence between 1988 and 2004 were identified using the Surveillance, Epidemiology, and End Results database. Univariate survival analysis was performed using the Kaplan-Meier method. Cox regression was used for multivariate analysis.ResultsCriteria for analysis were met in 747 patients. Of those, 24% underwent lumpectomy. On univariate analysis, patients undergoing lumpectomy had worse overall survival (P = .03). Five-year survival was 67% versus 78% for the lumpectomy and mastectomy groups, respectively. On multivariate analysis, mastectomy remained significantly associated with better survival with a hazard ratio of .5 (P = .003).ConclusionsThe use of lumpectomy for ipsilateral breast cancer recurrence previously treated with breast-conservation therapy should generally be discouraged.
Journal: The American Journal of Surgery - Volume 196, Issue 4, October 2008, Pages 495–499