کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4281196 1611589 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term survival after pancreatic cancer treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Long-term survival after pancreatic cancer treatment
چکیده انگلیسی

Pancreatic cancer is a nearly lethal disease. Patients have such a poor prognosis because there are no early symptoms. Upon presentation, most patients already have regional and systemic spread of the disease. With cure rates below 3%, long-term survival is difficult to measure. Thus, the assessment of clinical benefit has been based not only on observed 5-year survival but more frequently on actuarial, median, and disease-free survival. Surgery remains the only hope for cure, but median survival remains low despite improvements in peri- and postoperative treatment of complications and sharp decreases in perioperative morbidity and mortality. The addition of adjuvant chemo- and radiotherapy has provided a survival advantage of 6 to 10 months (increasing median survival to 20 months). However, the long-term benefit, if any, is still to be determined. Neoadjuvant therapies are also undergoing evaluation, but their role has not yet been established. True long-term survival may ultimately depend on the development of screening tools that will allow early detection (before regional and systemic spread) of this lethal disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 194, Issue 4, Supplement, October 2007, Pages S127–S130
نویسندگان
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