کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4282104 | 1611609 | 2006 | 5 صفحه PDF | دانلود رایگان |
BackgroundWe assessed the occurrence of long-bone fracture and other side effects in a group of 214 consecutive patients who underwent radical excision for soft-tissue sarcoma of the limb followed by postoperative irradiation.MethodsTwo hundred fourteen patients underwent postoperative irradiation after radical excision of soft-tissue sarcoma of the limb; 156 (73%) received postoperative brachytherapy (BRT) plus external-beam radiation therapy (EBRT), and 58 (27%) underwent postoperative EBRT only. All patients were followed-up for a median time of 4.5 years (range 3 months to 10 years).ResultsSeven patients developed bone fracture, which is considered severe morbidity; time between surgery and occurrence of fracture ranged between 10 and 72 months (average 31). Severe sclerosis with impairment of limb function was diagnosed in 5 and peripheral nerve damage in 3 patients. Wound complications were detected in 8 patients.ConclusionsIn our series, no statistically significant correlation between bone fracture and clinical features or “technical” parameters was found, but all of the patients who experienced bone fracture (7 of 7) were postmenopausal women >55 years old.
Journal: The American Journal of Surgery - Volume 191, Issue 2, February 2006, Pages 230–234