کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4282315 1611594 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Accuracy of pathologic examination in detection of complete response after chemoradiation for esophageal cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Accuracy of pathologic examination in detection of complete response after chemoradiation for esophageal cancer
چکیده انگلیسی

BackgroundAlthough a substantial proportion of patients undergoing neoadjuvant chemoradiation for invasive esophageal cancer develop a pathologic complete response (pCR), these patients nonetheless have a poor 5-year survival rate. We hypothesized that routine pathologic examination fails to identify some residual cancer.MethodsPatients undergoing esophagectomy for cancer at 2 tertiary care centers were identified. Archived tumor blocks were retrieved for patients with pCR, sectioned at 50-μm intervals and reexamined for residual cancer.ResultsSeventy patients underwent neoadjuvant chemoradiation. Tumor blocks were available for 23 of 26 complete responders. A total of 159 blocks were reexamined. One patient was found to have a possible focus of residual invasive adenocarcinoma versus high-grade dysplasia. The remaining 22 patients had no residual disease.ConclusionsA more aggressive examination protocol for postchemoradiation esophagectomy specimens may not result in significant upstaging. Inadequate pathologic examination is likely not a major factor in the suboptimal survival in patients with pCR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Surgery - Volume 193, Issue 5, May 2007, Pages 614–617
نویسندگان
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